Silica-Lipid Hybrid Microparticles for Improved Bioavailability of Bcs Class IV Drugs Vijay kumar Nagabandi*1, Swapna Sambaraj2 1M. Pharm., Ph.D., Assistant Professor, Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences, Vidyanagar, Hanamkonda, Andhrapradesh – 506001, India.
Biopharmaceutics classification system (BCS) class IV compounds, exhibits least oral bioavailability, low solubility and intestinal permeability among all pharmaceutical classes of drugs. Thus, these drugs need more compatible and efficient delivery system. Since, their solubility in various medium, remains a limitation so, polymeric nano coacervates based drug loading with modified approach for them may prove to be a solution ahead.